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Membrane Chemistry & Molecular Recognition
How proteins recognize specific lipids and how membrane composition controls those interactions.
Learn moreLaganowsky Research Laboratory
Decoding the chemistry of biological membranes
We investigate how lipids, metals, and the membrane environment control protein structure, interactions, and function.
Explore our researchOur perspective
Membranes aren’t just a solvent.
The unique chemistry and physical properties of membranes govern essential biological processes. Our laboratory combines native mass spectrometry, structural biology, biophysics, and protein engineering to define how membrane components regulate proteins at the molecular level.
Molecular detail
Native-like environments
Technology development
Collaborative science
Our research
Themes & approaches
We combine chemistry, structural biology, mass spectrometry, and protein engineering to understand how membranes encode biological function.
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Mechanosensation & Ion Channel Regulation
How lipids, metals, pressure, and membrane mechanics regulate K2P and Kir channels.
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Native Mass Spectrometry
Developing approaches to measure protein–lipid interactions, cooperativity, thermodynamics, kinetics, and intact assemblies.
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Structure in Native-like Membranes
Cryo-EM, Salipro, proteoliposomes, and complementary approaches in defined membrane environments.
Learn moreLatest discoveries
Featured publications
Time-Resolved Native Mass Spectrometry for Direct Measurement of Biomolecular Kinetics
A direct, label-free native MS approach for measuring biomolecular interaction kinetics.
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Temperature and lipid composition differentially regulate KRAS assemblies on membranes
Membrane composition and temperature tune KRAS assembly in distinct ways.
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Dissecting Heterogeneous Populations of Protein-Complex Samples Using Direct Mass Technology
Direct mass measurements resolve heterogeneous protein-complex populations that challenge conventional analysis.
Read paperOur team
Collaborative. Creative. Curious.
We are a group of scientists united by a shared interest in membrane proteins and the chemistry that regulates them.
Meet the labJoin the lab
Help us solve fundamental problems at the interface of chemistry and biology.
We are interested in hearing from motivated graduate students, postdoctoral researchers, and undergraduates who want to make an impact.
OpportunitiesLab life
Science is collaborative.
Seminars, conferences, celebrations, and life in College Station.
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